Stem Cell Therapy and Clinical Trails

With the advancement of Bioscience, there is enormous potential for Regenerative Medicine using stem cells from umbilical cord blood.

Latest Developments in UCB and UC Transplants2,3

Leukemia is a cancer of the blood immune system, where the cells are called leukocytes or white cells

DiagnosisAllogeneic
(Donor Cells)
Autologous
(Own Cells)
Acute Lymphoblastic Leukemia (ALL)
Acute Myelogenous Leukemia (AML)
Acute Biphenotypic Leukemia
Acute Undifferentiated Leukemia
Chronic Lymphocytic Leukemia (CLL)
Chronic Myelogenous Leukemia (CML)
Juvenile Chronic Myelogenous Leukemia (JCML)
Juvenile Myelomonocytic Leukemia (JMML)

Myelodysplastic Syndromes are also called pre-leukemia

DiagnosisAllogeneic
(Donor Cells)
Autologous
(Own Cells)
Refractory Anemia
Refractory Anemia with Ringed Sideroblasts (Sideroblastic anemia)
Refractory Anemia with Excess Blasts
Refractory Anemia with Excess Blasts in Transformation
Chronic Myelomonocytic Leukemia (CMML)

Lymphoma is a cancer of the leukocytes that circulate in the blood and lymph vessels

DiagnosisAllogeneic
(Donor Cells)
Autologous
(Own Cells)
Hodgkin’s Lymphoma
Non-Hodgkin’s Lymphoma (Burkitt’s Lymphoma)

Other Disorders of Blood Cell Proliferation

DiagnosisAllogeneic
(Donor Cells)
Autologous
(Own Cells)
Anemias are deficiencies or malformations of red cells:
Aplastic Anemia
Fanconi Anemia
(The first cord blood transplant in 1988 was for FA, an inherited disorder)
Congenital Dyserythropoietic Anemia
Paroxysmal Nocturnal Hemoglobinuria (PNH)
Inherited Red Cell Abnormalities
Red cells contain hemoglobin and carry oxygen to the body:
Sickle Cell Disease
Beta Thalassemia Major (aka Cooley’s Anemia)
Diamond-Blackfan Anemia
Pure Red Cell Aplasia
Inherited Platelet Abnormalities
Platelets are blood cells needed for clotting:
Amegakaryocytosis / Congenital Thrombocytopenia
Glanzmann Thrombasthenia
Inherited Immune System Disorders: Severe Combined Immunodeficiency:
SCID with Adenosine Deaminase Deficiency (ADA-SCID)
SCID which is X-linked
SCID with absence of T & B Cells
SCID with absence of T Cells, Normal B Cells
Omenn Syndrome
Inherited Immune System Disorders: Neutropenias
Infantile Genetic Agranulocytosis (Kostmann Syndrome)
Myelokathexis
Inherited Immune System Disorders: Other
Ataxia-Telangiectasia
Bare Lymphocyte Syndrome
Common Variable Immunodeficiency
DiGeorge Syndrome
Hemophagocytic Lymphohistiocytosis
Leukocyte Adhesion Deficiency
Lymphoproliferative Disorders
Lymphoproliferative Disorder, X-linked (Susceptibility to Epstein-Barr virus)
Wiskott-Aldrich Syndrome
Myeloproliferative Disorders:
Acute Myelofibrosis
Agnogenic Myeloid Metaplasia (Myelofibrosis)
Polycythemia Vera
Essential Thrombocythemia
Phagocyte Disorders
These are immune system cells that engulf and kill foreign organisms:
Chediak-Higashi Syndrome
Chronic Granulomatous Disease
Neutrophil Actin Deficiency
Reticular Dysgenesis
Bone Marrow Cancers:
Multiple Myeloma
Plasma Cell Leukemia
Waldenstrom’s Macroglobulinemia

Transplants for Inherited Disorders of the Immune System & Other Organs

DiagnosisAllogeneic
(Donor Cells)
Autologous
(Own Cells)
Cartilage-Hair Hypoplasia
Erythropoietic Porphyria
Hermansky-Pudlak Syndrome
Pearson’s Syndrome
Shwachman-Diamond Syndrome
Systemic Mastocytosis

Transplants for Inherited Metabolic Disorders

DiagnosisAllogeneic
(Donor Cells)
Autologous
(Own Cells)
Mucopolysaccharidosis (MPS) Storage Diseases:
Hurler Syndrome (MPS-IH)
Scheie Syndrome (MPS-IS)
Hunter Syndrome (MPS-II)
Sanfilippo Syndrome (MPS-III)
Morquio Syndrome (MPS-IV)
Maroteaux-Lamy Syndrome (MPS-VI)
Sly Syndrome (MPS-VII) (beta-glucuronidase deficiency)
Mucolipidosis II (I-cell Disease)
Leukodystrophy Disorders:
Adrenoleukodystrophy (ALD)
Krabbe Disease(Globoid Cell Leukodystrophy)
Metachromatic Leukodystrophy
Pelizaeus-Merzbacher Disease
Lysosomal Storage Diseases:
Niemann-Pick Disease
Sandhoff Disease
Wolman Disease
Other Inherited Metabolic Disorders:
Lesch-Nyhan Syndrome
Osteopetrosis

Solid tumors not originating in the blood or immune system

DiagnosisAllogeneic
(Donor Cells)
Autologous
(Own Cells)
Neuroblastoma
Medulloblastoma
Retinoblastoma

Neurologic Disorder

DiagnosisCord Blood
Allogeneic
(Donor Cells)
Cord Blood
Autologous
(Own Cells)
Cord Tissue
Allogeneic
(Donor Cells)
Alzheimer’s disease
Autism
Cerebral Palsy
Encephalopathy
Global Developmental Delay
Hearing Loss (acquired sensorineural)
Intraventricular Hemorrhage
Parkinson’s disease
Spinal Cord Injury
Stroke
Traumatic Brain Injury

Auto-Immune Disorders

DiagnosisCord Blood
Allogeneic
(Donor Cells)
Cord Blood
Autologous
(Own Cells)
Cord Tissue
Allogeneic
(Donor Cells)
Alopecia Areata
Amyotrophic Lateral Sclerosis (ALS)
Crohn’s Disease
Eczema (Atopic Dermatitis)
Graft-versus-Host Disease (GvHD)
Lupus
Multiple Sclerosis
Psoriasis
Rheumatoid Arthritis
Scleroderma
Systemic Sclerosis
Ulcerative Colitis

Cardiovascular

DiagnosisCord Blood
Allogeneic
(Donor Cells)
Cord Blood
Autologous
(Own Cells)
Cord Tissue
Allogeneic
(Donor Cells)
Acute Myocardial Infarction (Heart Attack)
Cardiomyopathy
Critical Limb Ischemia (CLI)
Heart Failure
Peripheral Arterial Disease (PAD)
Surgery for Congenital Heart Defects

Diabetic

DiagnosisCord Blood
Allogeneic
(Donor Cells)
Cord Blood
Autologous
(Own Cells)
Cord Tissue
Allogeneic
(Donor Cells)
Diabetes, Type 1
(this is Auto-Immune)
Diabetes, Type 2
Diabetic Foot Ulcer
Diabetic Peripheral Neuropathy

Genetic and/or Metabolic Disorders

DiagnosisCord Blood
Allogeneic
(Donor Cells)
Cord Blood
Autologous
(Own Cells)
Cord Tissue
Allogeneic
(Donor Cells)
Aging Frailty
Duchenne Muscular Dystrophy
Epidermolysis Bullosa
Hereditary Ataxia
Lysosomal Storage Diseases
Metabolic Syndrome
Severe Combined Immunodeficiency
Spinal muscular atrophy
Tay-Sachs Disease

Orthopedic

DiagnosisCord Blood
Allogeneic
(Donor Cells)
Cord Blood
Autologous
(Own Cells)
Cord Tissue
Allogeneic
(Donor Cells)
Ankylosing Spondylitis
Cartilage Injury
Cleft Palate Repair
Non-Union Fractures
Osteoarthritis
Osteochondral Lesion
Spinal Fusion Surgery

Other

DiagnosisCord Blood
Allogeneic
(Donor Cells)
Cord Blood
Autologous
(Own Cells)
Cord Tissue
Allogeneic
(Donor Cells)
Acute Respiratory Distress Syndrome (ARDS)
BronchoPulmonary Dysplasia (BPD)
(lung disorder due to premature birth)
Erectile Dysfunction
Eye Diseases
Fistula
HIV
Kidney Failure
Liver Cirrhosis
Liver Failure
Peyronie’s Disease
Premature Ovarian Failure
Uterine Scars
Wounds